ISR4221/K9 router with lifetime warranty. Cisco ISR4221 routers have 2 gigabit ethernet ports, 2 NIM slots, 1 ISC slot, 8 GB Flash Memory default, and 4 GB DRAM.


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Cisco 4221 with 2 onboard GE, 2 NIM & 1 ISC slot, 8 GB Flash, 4 GB DRAM.

Have a quick question regarding Cisco 4221 volume pricing or availability? Call us at 866-957-7373 for immediate info.

Cisco 4221 Platform Overview

Cisco ISR4221/K9 Port Diagram

Cisco refers to the ISR4221/K9 as the “Swiss army knife” of branch routers, and with good reason. The Cisco  4221 combines many networking tools into a single robust platform, including: Wireless WAN (3G/4G LTE and Cat6 LTE Advanced), Support for IWAN functionality, Wireless LAN, Integrated switch ports, VRF-aware firewall and NAT features, Multicore hardware VPN acceleration, Network contention control, Application services, Built-in security and more.

With the performance and feature sets of the enterprise ISR 4000 series in a small desktop-sized form factor, the Cisco 4221 is an ideal router for SMB and branch networking.


Cisco 4221 Datasheet Summary


ISR4221/K9 Technical Specifications Cisco 4221
Throughput (Default) 35Mbps
Aggregate Throughput (Performance License) 75 Mbps
Total onboard WAN or LAN 10/100/1000 ports 2
RJ-45-based ports 2
SFP-based ports 1
NIM slots 2
Default memory double-data-rate 3 (DDR3) error-correction-code (ECC) DRAM (Combined control/services/data planes) 4GB
Default flash memory 8GB
External USB 2.0 slots (type A) 1
Serial console port – RJ45 (up to 115.2 kbps) 1 (combo CON/AUX port)
Serial auxiliary port – RJ45
(up to 115.2 kbps)
1 (combo CON/AUX port)
Power-supply options External AC only
(H x W x D)
1.72 x 12.7 x 10″

(43.7 x 322.6 x 254 mm)

Rack height 1 Rack Unit (1RU)
Rack-mount 19in. (48.3 cm) EIA Optional
Wall-mountable Yes
Cisco 4221 FAQs

Does the Cisco ISR4221/K9 come with a power supply?

Yes, the Cisco 4221 ships with a 12v external AC power supply that is required for operation.

Does the Cisco ISR4221/K9 support voice services?

 No, the ISR4221/K9 does not support UC features, so no V, VSEC or AVX bundles for this platform exist.

For a small business ISR 4000 that supports voice, you may want to check out the Cisco ISR4321-V/K9.

Can I Smart Net a ISR4221/K9 router from P3 Systems?

Yes – all of our ISR4221/K9 are ‘clean’, genuine and smartnet eligible. If you have concerns about the exact unit you will be receiving, such as country of origin, smart net status, hardware revision, or other specifics please contact us. We’d be happy to provide any information we can to put your mind at ease!


Need pricing on a new, refurbished or Cisco Excess ISR4221/k9? Have an ISR or other equipment to sell? Get a quote today!
Cisco 4221 Router

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Weight 7.1 lbs
Dimensions 10 × 12.7 × 1.72 in

New, Refurbished

Total 10/100/1000 Ports


RJ45 Ports


SFP Ports


NIM Slots



35Mbps (Default), 75Mbps (Performance License)


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